Possible mechanism of metabolic and drug resistance with L-asparaginase therapy in childhood leukaemia
L-asparaginase, which hydrolyzes asparagine into aspartic acid swish supreme glide track white and ammonia, is frequently used to treat acute lymphoblastic leukaemia in children.When combined with other chemotherapy drugs, the event-free survival rate is 90%.Due to immunogenicity and drug resistance, however, not all patients benefit from it, restr